Professor Brookes is an expert in genomics and bioinformatics, with experience in disease and population genetics, DNA variation analysis, and biomedical data management/exploitation systems. He has published over 150 peer-reviewed articles and reviews. He has served two 3-year terms on the HUGO Council, co-founded the Human Genome Variation Society, leads an international meeting series on genome variation, jointly designed the standard ‘PaGE-OM’ and ‘Observ-OM’ data models for genotype-phenotype information, and filed 6 patent applications on cloning, genotyping, and DNA analysis methods. In his current position as Professor of Bioinformatics and Genomics at the world-renowned Genetics department of the University of Leicester (UK), he is continuing these areas of work, with a focus upon methods for DNA diagnostics, and bioinformatics to enable systems medicine. This is reflected, not least, in his key roles in the EU and UK consortium projects GEN2PHEN (www.gen2phen.org), READNA (www.cng.fr/READNA), BioSHaRE (www.bioshare.eu), COPDMAP (http://copdmap.com) and EMIF (www.imi.europa.eu/content/4th-call-2011).