This website provides access to public databases and bioinformatic tools. The resource includes data on nucleic acid and protein sequences and macromolecular structures. EBI is a centre for research and services in bioinformatics and an outstation of the European Molecular Biology Laboratory (EMBL).
The Biobank TOOLKIT provides a one-stop location for access to biobanking tools.
Tools are searchable by:
The Framework for Responsible Sharing of Genomic and Health-Related Data has been developed under the auspices of the Regulatory and Ethics Working Group of the Global Alliance for Genomics and Health, in collaboration with many individuals, organizations and committees around the world. (2014)
Display P3G documents
The Medical Research Council (MRC) has developed a framework on the feeddback of health-related findings in research to help researchers identify and consider the relevant issues when designing and implementing a policy on the feedback of health-related findings in research. (2014)
This website aims to unify human- and model-organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The GEN2PHEN Knowledge Centre has received funding from the European Community's Seventh Framework Programme.
This website displays an archive of the results of genetic association studies of complex human diseases and disorders. This updatable database uses standardized nomenclature to allow the user to search on the basis of disease, genetic variant or other criterion, to rapidly identify clinically relevant genetic associations from the huge volume of polymorphism and mutational data that exist. A National Institute of Health-maintained website.
This website provides access to automated analysis of statistical power for variance components (VC), quantitative trait locis (QTL) linkage and association tests in sibships, and other common tests. Constructed by Shaun Purcell based on work by himself and Pak Sham originally carried out at the Institute of Psychiatry (London), and maintained by the Psychiatric and Neurodevelopmental Genetics Unit at Harvard University.
GenoByte is a Java API for storing and querying data resulting from the aggregation of high-throughput genotyping experiments across many subjects. GenoByte was developed at the McGill University and Génome Québec Innovation Centre to accomodate the needs of the Genotyping Platform which handles such volumes of data routinely for its customers. Existing approaches for handling this data were becoming too slow. By introducing GenoByte in the in-house system substantial performance gains were achieved. Led by the OBiBa software project.
This website, from Gonçalo Abecasis' research group, emphases on developing computational and statistical software required for understanding human genetic variation, with a particular focus on complex human disease and encompassing both linkage and association analysis. The website provides access to a number of packages widely used by genetic epidemiologists including Merlin, QTDT and Gold. Website maintained by the University of Michigan.
This website presents this project which has undertaken a global analysis of polymorphism patterns and of linkage disequilibrium across the human genome. Based on informatics tools including the genome browserExternal, this information has many uses - for example, it can be used to guide selection of tag SNPs across the entire human genome. HapMap is based on an international partnership of scientists and funding agencies from Canada, China, Japan, Nigeria, the United Kingdom and the United States.
This document aims to help biomedical researchers undertaking studies and systematic reviews in human genome epidemiology to take sensible decisions about methods right through from study design to final analysis. A HuGENet Systematic Review and Meta-Analysis Working Group handbook (2006).
This website discusses three main issues. First, it helps in locating tumor specimens and related data of interest. Legal and ethical issues are addressed and a model informed consent and patient information sheet are available. Finally, issues relating to the establishment and management of a tissue bank are discussed. The website is maintained by the Cancer diagnosis program of the National Cancer Institute (NCI).
36. Human Tissue Repositories: Best Practises for a Biospecimen Resource for the Genomic and Proteomic Era
This document identifies technical; operational; and ethical, legal, and policy best practices in order to ensure a level of consistency and standardization across biospecimen resources. (2011)